The pair had helped identify a still-unnamed disease, which they had tied to a particular gene and to a particular somatic mutation—a genetic change that had not been passed down from a parent and was ...

Germline gene therapy and somatic gene therapy are two quite different proposals, and the legitimate concerns and risks of the former should not be used to stall progress on the latter.

(A) Hypothetical pedigree of Segmental neurofibromitosis type 1, and (below) molecular analysis showing somatic mosaicism ... molecular analysis showing germ-line mosaicism in tuberous sclerosis.

A recent study published in Cell reveals that the repeated DNA sequence that leads to Huntington’s disease (HD) expands ...

This process is commonly reverted in cancer cells (i.e. a soma-to-germline transition) and is intentionally reversed when mammalian somatic cells are reprogrammed into induced Pluripotent Stem Cells.