Articles were selected for inclusion if they reported on patients with metastatic prostate cancer who received a germline or somatic genomic test and/or made comparisons between those tests, reported ...

(A) Hypothetical pedigree of Segmental neurofibromitosis type 1, and (below) molecular analysis showing somatic mosaicism ... molecular analysis showing germ-line mosaicism in tuberous sclerosis.

Germline gene therapy and somatic gene therapy are two quite different proposals, and the legitimate concerns and risks of the former should not be used to stall progress on the latter.

He adds, “it’s not clear that the mutation rate differs between somatic vs. germline . . . and if it does not, then nothing is gained or lost” in terms of how much variation parents are providing to ...

In a single test, WGS can detect somatic small variants, including single nucleotide ... Patients with this cancer type had an earlier cancer onset if they carried predisposing germline variants. “If ...

IVIRMA Global Research Alliance and Imperial College London asked whether the infertility and ovarian aging phenotype caused by global germline deletion of Clpp is associated with somatic aging ...

This process is commonly reverted in cancer cells (i.e. a soma-to-germline transition) and is intentionally reversed when mammalian somatic cells are reprogrammed into induced Pluripotent Stem Cells.