which enter the spinal cord via the dorsal root. Some of these nerve fibers form connections with other nerves in the dorsal horn, whereas some fibers directly continue up to the brain.

They discovered that over 90 percent of neurons in the dorsal horn - the sensory processing area of the spinal cord - responded to light touch. "This was surprising because classically it was ...

In many cases, the pain cannot be relieved with analgesics. In humans, the spinal cord dorsal horn acts as a sorting station for pain stimuli. Signals coming in from peripheral areas of the body ...

Section of mouse dorsal horn spinal cord. Blue marks cell nuclei, red the neurons. Green highlights the acetylation level of histone 3, used to measure the activity of HDAC4. This image may be ...

Nociception can be amplified by dorsal-root ganglia and changes in the dorsal horn of the spinal cord (top inset). The afferent neurons are sensitized by the sprouting of new axons around the cell ...

AAV virus-mediated spinal cord-specific knockout or pharmacological inhibition of ErbB4 also blunted the response to thermal pain. Based on these results, we propose that ErbB4 is a functional marker ...

Notably, that tolerance and hyperalgesia continue at least one week after morphine withdrawal, suggesting that the sustained morphine treatment triggered plasticity in nerve function in the spinal ...

Spinal cord stimulation consists of leads placed in the epidural space alongside the dorsal column and then tunnelled subcutaneously to an implantable pulse generator. These generators contain a ...