A mixture of proteins and other cellular components obtained by breaking open cells. In this study, tumor lysates were used to present a broad array of cancer antigens to the immune system. Overcoming ...

SNAs also enable scientists to tailor how these vaccine components are presented ... The team developed a cancer vaccine that doubled the number of cancer antigen-specific T cells and increased ...

Cancer immunotherapy is a therapy used to treat cancer patients that involves or uses components of the immune ... By tracking tumor antigens and tumor-reactive T cell clones in serial tumor ...

However, not all tumor cells are easily ... so to speak. As antigen-presenting cells, they are able to break down the foreign cell components into smaller pieces and then present them as peptides ...

Despite harboring the highest tumor mutational burden of all cancers, basal cell carcinomas (BCCs) have low immunogenicity. Loss of human leukocyte antigens class I (HLA-I) components is ...

Thus, identifying dietary components that prevent or inhibit ... AFDs to determine how the addition of these food antigens may affect tumor proliferation and immune responses.

Unlike a CAR, which only detects antigens expressed on the surface of a cell, a TCR can also access the intracellular cancer proteome. This is the result of an elegant evolutionary process that ...

Certain tumor markers may provide information about pancreatic cancer. Cancer antigen 19-9 (CA 19-9) is a type of tumor marker. Antigens are substances that cause the immune system to respond.

They recognize a specific target—an antigen—on the surface of the cancer cell and bind to it. Once a T-cell has bound to the cancer cell it can signal for other immune cells to destroy it.

Chimeric antigen receptor T cell (CAR-T) therapy has dramatically improved the odds for patients with blood cancer, boosting survival rates from 15% to 40% for some types. But despite ongoing ...

Additionally, certain tumor antigens, or molecules that immune cells recognize as threats, disappeared from the cancer cells. This may have allowed the tumors to escape immune detection.