One major challenge in stem cell research has been to reprogram differentiated cells to a totipotent state. Researchers from RIKEN in Japan have identified a duo of histone proteins that dramatically ...

Totipotency is set to become a key tool for research and future medical applications. Finding efficient ways to generate totipotent-like cells is therefore crucial. In a new study, a group of ...

Stem cells are characterized according to their degree of potency, which refers to their varying ability to differentiate into different cell types. Totipotent cells are the most potent of all stem ...

Researchers at the University of Pennsylvania have created the first mammalian gametes grown in vitro directly from embryonic stem cells. The work, in which mouse stem cells placed in Petri dishes -- ...

Many attempts have been made to induce high-quality embryonic stem cells such as pluripotent stem cells and totipotent stem cells, but challenges remain to be overcome such as appropriate methods and ...

The development of stem-cell-derived models of mammalian embryogenesis has provided invaluable tools for investigating embryo development. However, constructing embryo models that can continuously ...

This study identifies DUX-mediated phase separation as a key driver for 3D genome reorganization and super-enhancer assembly, licensing totipotency gene expression and providing mechanistic insights ...

Totipotent cells own the highest differentiation potential of all cells. They can only be found shortly after fertilization in an early embryonic state and are capable of producing all cell types.

One major challenge in stem cell research has been to reprogram differentiated cells to a totipotent state. Researchers from RIKEN in Japan have identified a duo of histone proteins that dramatically ...

In development of human, the egg cell (from a women) and the sperm cell (from a man) fuse together to form a single cell called the zygote. The zygote divides multiple times to form 216 different cell ...