We often take facts we learn — like the fact that transcription factors bind to DNA — for granted. Or maybe not. See how researchers used DNA footprinting and gel shift assays to prove this idea.

The interactions between transcription factors guided by DNA are poorly understood. In a new study, researchers from the Sanger Institute and the University of Cambridge used two novel algorithms ...

Transcription factors are proteins that bind to specific DNA sequences to control gene expression, guiding cells to become ...

Investigating how mutations in tumors alter DNA’s 3D structure—and subsequently, regulatory sequences called enhancers—can ...

Zhiyuan Xie et al. (2025) ‘DNA-guided transcription factor interactions extend human gene regulatory code.’ Nature. DOI: 10.1038/s41586-025-08844-z . Funding: ...

In the field of molecular biology, a transcription factor (sometimes called a sequence-specific DNA binding factor) is a protein that binds to specific DNA sequences and thereby controls the ...

In diseases due to exposure to toxic particles like gout, macrophages elicit separate pathways for inflammation and lysosomal ...

The team applied this tool to immature blood cells to identify the important transcription factors – and DNA regions that code for them – that strongly affect how blood cells develop. They discovered ...

For years, scientists have considered transcription factors to be undruggable, but new research published this month in Molecular Cell shows they may be druggable after all (2024, DOI: 10.1016/j ...

Our laboratory investigates how transcription factors, DNA damage response proteins, and epigenetic modifications induce changes in the structure, dynamics, and interactions of chromatin. We are also ...

Transcription factors are proteins that bind to specific DNA sequences to control gene expression, guiding cells to become specific types—such as skin, muscle, or placenta cells.