For the first time scientists have identified promising drug candidates that bind irreversibly with a notoriously "undruggable" cancer protein target, permanently blocking it.

If DNA is a book, then how is it read? Learn more about the DNA transcription process, where DNA is converted to RNA, a more portable set of instructions for the cell. The process of transcription ...

A research team led by Prof. Cao Xiaofeng at the Institute of Genetics and Developmental Biology (IGDB) of the Chinese ...

A new method for mapping torsion provides insights into the ways that the genome responds to the torsion generated by RNA polymerase II.

First, Lear's team helped to create tagged transgenic strains for more than 90% of known transcription factors in the fruit fly genome; collaborators at Yale generated tagged transgenic strains ...

This image illustrates the process of gene transcription within a cell. The DNA double helix unwinds to expose a specific sequence, allowing RNA polymerase to synthesize a complementary pre-mRNA ...

"Each gene was like a single word. However, there was a piece of critical information lacking: transcription initiation sites for individual genes." Transcription initiation sites are locations in ...

With the long-term goal of creating living cells from non-living components, scientists in the field of synthetic biology ...

A recent study has unveiled the critical roles of two transcription factors, MAFB and CEBPA, in the development of ...

Chronic hepatitis B virus (HBV) infection continues to pose a major global health threat. The virus evades immune responses and antiviral therapies due to the persistence of covalently closed circular ...