The evolutionarily conserved mediator of RNA polymerase II transcription (Mediator) complex is a general regulator of transcription. Recent structural and functional studies have provided ...

Every day, our bodies perform around 330 billion cell divisions to keep us alive and functioning. These divisions rely on the ...

Transcription Regulation; Publications; Resources; Structural Gallery; Contact. Phone. 713–798–8668. Fax. 713–796–9438. Email. [email protected]. Tsai Lab Project: Transcription Regulation. Master.

The challenge lies in dissecting the individual contributions of the many complex factors involved in such regulation -- chromatin marks, transcription factors, and regulatory DNA sequences.

While the biology of CTCF has been extensively studied, how the different domains (parts) of CTCF function in relation to transcription regulation remains unclear.

Using this system, we identified the rules that govern CTCF-dependent transcription regulation." Chunliang Li, Ph.D., Co-Corresponding Author, St. Jude Department of Tumor Cell Biology ...

Richter, WF; Nayak, S; Iwasa, J; Taatjes, DJ. The Mediator complex as a master regulator of transcription by RNA polymerase II. Nat Rev Mol Cell Biol 2022, 23: 732 - 749. Palacio, M; Taatjes DJ.

Understanding human biology requires more than mapping our genes—we must also understand how gene expression is regulated to ...

A recent study from the Institute of Biomedicine at the University of Eastern Finland shows that the glucocorticoid receptor can both promote and inhibit prostate cancer progression, depending on the ...