The transduction of extracellular signals across the membrane to initiate complex cascades of molecular events regulates ... tyrosyl-regulation of Src-family and Syk-family protein tyrosine kinases in ...

Intracellular signaling by receptor tyrosine kinases regulates many different aspects of cell behavior. Recent studies in our laboratory and others have demonstrated that the EphA2 receptor ...

Upon ligand stimulation, different plexins were found to interact with cytoplasmic or receptor tyrosine kinases (RTKs ... intracellular signalling cascades. Moreover, the cytoplasmic domain ...

One of the proteins, called epidermal growth factor receptor (EGFR), belonged to a group called receptor tyrosine kinases (RTK ... triggering a cascade of biochemical reactions that enable ...

initiating a cascade of signaling pathways that result in responsively altered DNA expression. Aberrant signaling originating from mutated tyrosine kinases has been shown to be a major driving ...

Protein tyrosine kinases and protein tyrosine phosphatases coordinate to ... The emergence of pseudokinases and pseudophosphatases has made phosphorylation cascades even more complicated. My lab ...

Boston): "RAS plays a central role in receptor tyrosine kinase (RTK)-stimulated signaling pathways, including those stimulated by nerve growth factor (NGF). "This paper shows that RAS functions to ...

Many successful cancer drugs -- such as Gleevec, which is used for the treatment of leukemia, -- specifically target wayward tyrosine kinases. This treasure trove of diverse and novel tyrosine ...

Kinases mostly act on both serine and threonine, but tyrosine kinase acts on tyrosine only and some dual-specificity kinases act on all three of these amino acid residues. Some protein kinases ...

It shows a high degree of specificity for BCR-ABL, the receptor for platelet-derived growth factor, and c-kit tyrosine kinases. 11 STI571 causes arrest of growth or apoptosis in hematopoietic ...