A cross-country storm will explode in strength as it moves over the central United States Friday, delivering extreme weather to millions through the weekend, including the chance of multiple strong tornadoes.

A sweeping storm system moving across the U.S. threatens to bring tornadoes, blizzards and possibly wildfires to different regions of the country.

The forecast comes days after an expansive storm similarly trekked across the U.S. last week, unloading snow in the northern Plains and bringing tornadoes and wildfires to the South. At least five storm-related deaths in Nebraska and Mississippi were tied to that storm.