VHL is one of those diseases that you learn about in medical school but rarely see in practice, if ever. The NIH specializes in these “zebras.” ...

Cause. VHL syndrome is caused by mutations in certain tumor suppression genes (3p25-26), which results in highly vascular tumors. The genetic mutation is usually inherited from a parent who is ...

Constitutive activation of the HIF transcription factor is responsible for the hypervascularization that occurs in VHL-disease–associated renal cell carcinoma. 1,7,8 Accordingly, VEGF-targeted ...

Inactivation of the von Hippel–Lindau (VHL) tumour-suppressor gene is linked to the development of several different tumour types in humans, including tumours of the kidney, retina, central ...

Feb. 10, 2011 — -- In a multi-episode arc on "Grey's Anatomy," actor Scott Foley plays a von Hippel-Lindau (VHL) patient, diagnosed with a dangerous adrenal tumor. Doctors at the ABC show's ...

The company recently secured a worldwide licence for LaNova Medicines’ LM-299. "MSD’s WELIREG approved by NMPA to treat VHL disease-associated tumours" was originally created and published by ...

Von Hippel-Lindau (VHL) syndrome is a rare genetic disorder inherited in an autosomal dominant manner. The disease is characterized by hemangioblastomas or slow-growing vascular tumors of the ...