X-chromosome inactivation varies across different areas of brains. Here, fluorescent imaging data from a mouse reveal where the father’s X chromosome is most active (white) and least active (blue). A ...

The silencing of the one X chromosome in XX cells is mediated by XIST, a long noncoding RNA that is randomly transcribed from only one X early in development. It coats the DNA and shuts down gene ...

Females carry two X chromosomes, after inheriting one from each parent. In order to stop serious problems from arising, cells of the body silence one of those X chromosomes in a process known as X ...

Eighty percent of patients with autoimmune diseases are female. These diseases are one of the top 10 leading causes of death for women under 65, and cases are increasing annually worldwide. There is ...

Women are born with two X chromosomes and inherit one from each parent. But in every cell of their body, just one X chromosome is needed—so the other is randomly inactivated. Some cells use only a ...

Conventional investigations of the genetic contributors to Alzheimer's disease (AD) risk and progression have ignored the role of the X-chromosome, primarily due to technical analysis limitations. To ...

Shaped by thousands of years of evolution, the body’s immune system is a vigilant guardian primed against external infectious threats. Too much vigilance, however, and this guardian of potent cells ...

Researchers at Linköping University in Sweden made an unexpected discovery while investigating genetically unique women. Their insights advance our understanding of our most enigmatic chromosome, the ...