BALTIMORE - The skidding Baltimore Orioles lost to the San Francisco Giants, 5-3, Wednesday night at Camden Yards. Mike Yastrzemski homered on the game's first pitch, Michael Conforto also hit a solo shot for the Giants, who took the first two games in the series.

After a difficult second half, erratic closer Craig Kimbrel has been designated for assignment by the contending Baltimore Orioles.

Baltimore Orioles relief pitcher Craig Kimbrel (46) returns to the dugout during a pitching change after he gave up six runs during the ninth inning of a baseball game against the San Francisco Giants,

The Baltimore Orioles announced that they have designated relief pitcher Craig Kimbrel for assignment. Right-handed pitcher Bryan Baker has been recalled

It was a foregone conclusion for weeks, but the Giants officially saw their postseason chances reach zero in another heartbreaking loss.