Today, scientists know that the Okazaki fragments of bacterial DNA are typically ... (As mentioned, DNA synthesis can proceed only in the 5'-to-3' direction.) If there were no way to fill this ...

This allows the lagging-strand polymerase to remain at the fork after it finishes the synthesis of each Okazaki fragment. As a result, this polymerase can be used over and over again to synthesize ...

the fill-in synthesis of the C-rich strand via short DNA fragments (Okazaki fragments) surprisingly could not keep up in these cells. “Not only did it not elongate, but it also got shorter,” said de ...

An analogous process occurs during chromosomal DNA replication, whereby the 5’-RNA segments that prime discontinuous synthesis of Okazaki fragments are excised, and the intervening gaps are filled in ...