Lysine acetylation is a reversible post-translational modification that plays a critical role in modulating protein function, stability and interactions across a range of organisms. This modification, ...
Santosh Kumar, Young-Rae Kim, Ajit Vikram, Asma Naqvi, Qiuxia Li, Modar Kassan, Vikas Kumar, Markus M. Bachschmid, Julia S. Jacobs, Ajay Kumar, Kaikobad Irani Proceedings of the National Academy of ...
Recently, a research team led by Prof. Huang Qing from Hefei Institutes of Physical Science (HFIPS), Chinese Academy of Sciences (CAS) used infrared and Raman spectroscopy to identify lysine ...
Researchers have unveiled a new mechanism for regulating mitochondrial function. The findings reveal the critical role played by the enzymatic activity of the lysine acetyltransferase MOF in ...
The chromatin regulators CBP and p300 maintain gene expression programs through lysine acetylation of chromatin and transcriptional regulators and by scaffolding functions mediated by several ...
Even a small change may cause long-term consequences. For amyloid beta peptides, a major hallmark of Alzheimer's disease, a common chemical modification at a particular location on the molecule has a ...
Sometimes proteins misfold. When that happens in the human brain, the pileup of misfolded proteins can lead to neurodegenerative diseases like Alzheimer's, Parkinson's and ALS. Proteins do not ...
PHILADELPHIA-- New findings suggest that late-onset Alzheimer's Disease is driven by epigenetic changes -- how and when certain genes are turned on and off -- in the brain. Results were published ...
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