Parecoxib sodium is an amide prodrug of valdecoxib, a novel oral COX-2-specific inhibitor. Parecoxib sodium has no inhibitory activity on either COX-1 or COX-2; all enzyme inhibitory effects are ...

Gene-directed enzyme–prodrug therapy (GDEPT) 6 is a method of treating tumours that should be capable of significantly reducing the undesirable side effects of cancer treatment. This Perspective ...