Balancing act of a leading strand DNA polymerase-specific domain and its exonuclease domain promotes genome-wide sister replication fork symmetry. Meng X, Claussin C, Regan-Mochrie G, Whitehouse I, ...

Our lab studies the mechanism of eukaryotic chromosome replication. Chromosomes are the carriers of the genetic and epigenetic information and faithful chromosome replication is of fundamental ...

The accurate replication of genetic material DNA is one of the most fundamental biological processes essential for the survival, growth, and reproduction of all living organisms. Eukaryotes, including ...

In mitosis, DNA replication is initiated through the actions of various multiprotein complexes that recognize the start sites within a chromosome and cause the separation of DNA into two ...