Real Madrid overcame a missed Vinicius Junior penalty in regulation to advance to the quarterfinal round, where they will play Arsenal.

Some of the best players in European soccer are set to clash when Real Madrid and Atlético Madrid meet in the Champions League round of 16.

Real Madrid knocked Atlético out of the Champions League yet again, triumphing on penalties to book their place in the quarter-finals.

Real Madrid eked out a 2-1 home victory over crosstown rivals Atletico Madrid, while Arsenal and Aston Villa scored emphatic first-leg victories as the Champions League last 16 kicked off on Tuesday. In the night's fourth tie, Lille gained a 1-1 draw at Borussia Dortmund.

Real Madrid's goalkeeper Thibaut Courtois, left, makes a save in front Atletico Madrid's Antoine Griezmann, center, during the Champions League round of 16 first leg soccer match

Real Madrid beat Atletico Madrid in a Champions League penalty shootout — again — to keep its title defense alive Wednesday and advance to the quarterfinals

There is almost always drama when local rivals Real Madrid and Atlético Madrid play each other, but Wednesday’s match in the last 16 of the Champions League takes some beating.

Real Madrid beat city rivals Atletico 4-2 on penalties to reach the Champions League quarter-finals following an enthralling last-16 tie which ended 2-2 after extra time in a raucous atmosphere at Metropolitano on Wednesday.