Levofloxacin inhibits bacterial topoisomerase IV and DNA gyrase (both of which are type II topoisomerases), enzymes required for DNA replication, transcription, repair and recombination.

Unlike a band that would unwind if released, DNA gyrase stabilises DNA's twisted form, making it functional for bacteria. The enzyme wraps DNA in a 'figure-of-eight' loop, then precisely breaks ...

Levofloxacin 25mg/mL; contains benzyl alcohol. Levofloxacin inhibits bacterial topoisomerase IV and DNA gyrase (both of which are type II topoisomerases), enzymes required for DNA replication ...

triazaacenaphthylene antibacterial that inhibits bacterial DNA replication by a distinct binding site and unique mechanism of ...