Here we discuss chemical tools and detection methods that could be effectively combined to make significant progress in understanding the dynamics of intracellular signaling pathways ...

Understanding how bacteria form communities on surfaces, including biofilms, has significant implications for both health and ...

The p38 MAPK regulates intracellular signaling pathways in response to environmental stress. Its inhibition blocks the production of inflammation-causing cytokines, such as IL-1β and TNF-α ...

The protein QRICH1 is a recently identified component of a signaling pathway of CD8 + cells ... Carter et al, QRICH1 mediates an intracellular checkpoint for CD8 + T cell activation via the CARD11 ...

As a master regulator of cellular growth and development, steroid receptor coactivator-3 (SRC-3) sits at the nexus of many intracellular signaling pathways critical for cancer proliferation and ...

A cell signaling mechanism of fundamental importance to animal development is the Notch pathway (Figure 1). It may be safely said that Notch signaling is required, in some reasonably direct fashion, ...