Here we discuss chemical tools and detection methods that could be effectively combined to make significant progress in understanding the dynamics of intracellular signaling pathways ...

The p38 MAPK regulates intracellular signaling pathways in response to environmental stress. Its inhibition blocks the production of inflammation-causing cytokines, such as IL-1β and TNF-α ...

A cell signaling mechanism of fundamental importance to animal development is the Notch pathway (Figure 1). It may be safely said that Notch signaling is required, in some reasonably direct fashion, ...