Therefore, there is a huge unmet clinical need. Receptor tyrosine kinase–like orphan receptor 2 (ROR2) is a non-canonical WNT receptor that regulates the planar cell polarity pathway, controlling limb ...

Background We previously reported that ROR2 blockade (ROR2i) induces chondrogenesis in vitro and in vivo, improving pain and cartilage integrity following joint destabilization in mice (Thorup et al., ...