Early decisions can impact the success of a novel gene therapy, so how can therapeutics companies make sure to set off on the right track? In this article, drug developers will learn some things that ...

Ingress of carbon dioxide into bulk drug substance (BDS) containers that are stored and shipped on dry ice is a serious and often understated problem. Bottles are a container of choice for freezing ...

As gene therapies continue to stake their foothold on the clinical trial landscape and comprise the future wave of lifesaving pharmaceuticals, high-quality GMP-grade plasmids are increasingly in ...

Cell and gene therapies have reached clinical and commercial success as evidenced by the steady number of first approvals over the past four years. Drug developers face mounting challenges linked to ...

Moderator: Anna Brown, Conference Producer, Informa. Featuring: Christian Witz, CEO, Sim Vantage. In this interview from BPI Europe in May 2023, Christian Witz, CEO, Sim Vantage discusses its use of ...

Figure 1: (a) Cell and gene therapy development pathway from patient/donor (red) to recipient (blue); (b) subcellular molecules and ions important for effective cell and gene therapy cultures ...

Prokaryotic and eukaryotic cells change and adapt to their environments in ways that genomic characterization methods do not fully capture or predict. Even strains of the same species of microbe can ...

In vitro transcription (IVT), the enzymatic process used for the production of mRNA vaccines, differentiates itself from biological fermentation processes by the need for linearized plasmid DNA. The ...

Vaccines have been protecting against disease since the late 1700s. They function by triggering the immune system to generate short-term and long-term responses. Because there are many pathogens, ...

Mitochondria originated millions of years ago, likely when a eukaryotic cell incorporated a bacterium. Thus, mitochondrial DNA strands are 200,000× smaller than those from a cell’s nucleus. Depending ...

Be the catalyst for change and experience the future of bioprocessing. Slash biologics development costs, supercharge your pipeline, and deliver transformative therapies with precision, quality, and ...

Dare to use preparative chromatography at industrial scale to lead your API to success. Pharmaceutical development is evolving at an unprecedented pace, with active pharmaceutical ingredients (APIs) ...