Characterization of the first class D β-lactamases in Gram-positive bacteria, including the Bacillaceae family, shows that one, BPU-1, is capable of hydrolyzing a wide variety of β-lactam ...

AmpC β-lactamases are chromosomally encoded cephalosporinases intrinsic to all A. baumannii. Usually, such β-lactamases have a low level of expression that does not cause clinically appreciable ...

Table 3. Genetic environment of the VIM-type metallo-β-lactamases associated with class 1 integrons. VIM Gene cassette(s) between 5'-CS and 3'-CS ...

The story of the beta-lactamases is a case in point. ... Updated functional classification of β-lactamases. Antimicrob Agents Chemother 2010;54:969-976. Crossref. PubMed. Web of Science.

AmpC β-lactamases are chromosomally encoded in many bacterial species. Their overexpression can lead to resistance to most β-lactam antibiotics, causing therapeutic failure. Transmissible plasmids ...

Metallo-beta-lactamases were the most frequently identified carbapenem resistance mechanism among Enterobacterales isolates in IHMA global surveillance. August 14, 2023 07:00 AM Eastern Daylight Time.

The primary focus of our laboratory is to understand the genetic and amino acid sequence determinants of the enzymes that inactivate ß-lactams, the ß-lactamases. Our current work is directed at ...

Table 3. Genetic environment of the VIM-type metallo-β-lactamases associated with class 1 integrons. VIM Gene cassette(s) between 5'-CS and 3'-CS ...