† VIMs are made up of 266 amino acid residues with the exception of VIM-7 (265 residues) and VIM-18 (262 residues). VIM-21, -22 and -27 have been assigned in the Lahey Clinic [201], but there ...

Epidemiology and Genetics of VIM-type Metallo-β-lactamases in Gram-negative Bacilli Wei-Hua Zhao; Zhi-Qing Hu Disclosures Future Microbiol. 2011;6 (3):317-333.

Among the β-lactamases the production of ESBLs and AmpC β-lactamases are the most common (10). AmpC β-lactamases are class C or group I cephalosporinases that confer resistance to a wide variety of ...

Group I β-lactamases are major resistance determinants to β-lactam antibiotics. Despite intense study, the identity of the catalytic base, the direction of hydrolytic attack, and the functional ...

AbbVie has claimed FDA approval for Emblaveo, a new antibiotic product to treat complicated intra-abdominal infections (cIAI), including those caused by Gram-negative bacteria that represent a ...

The biochemical properties of CMY-32, a class C enzyme possessing a single-amino acid substitution in the Ω loop (Gly214Glu), were compared to those of the parent enzyme, CMY-2, a widespread class C β ...

Trends in Production of Extended-Spectrum β-Lactamases among Enterobacteria of Medical Interest: Report of the Second Italian Nationwide Survey. J. Clin. Microbiol., 44 (5): 1659-1664. 9. Paterson, ...