Department of Pharmacy, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China Introduction: Prior cohort studies reported paradoxical results between proton pump inhibitor (PPI) ...

Interest in developing selective inhibitors has produced tool compounds for the inactivation or degradation of AKR1C3 with varying degrees of selectivity among the 14 known AKR proteins. Selectivity ...

It is taken with an aromatase inhibitor to reduce oestrogen levels. Common side effects include fatigue, anaemia, infection risk, rash, dizziness, and gastrointestinal symptoms. NICE said that ...

Led by AbbVie’s Humira, biologic TNF inhibitors transformed the treatment of autoimmune diseases over the past 20 years. However, the biologic modality can cause adverse effects and loss of ...

NEW YORK – The National Institute for Health and Care Excellence (NICE) is recommending Novartis' Kisqali (ribociclib) plus an aromatase inhibitor for certain patients with early-stage breast cancer ...

Today, the National Institute for Health and Care Excellence (NICE) published its preliminary optimised recommendation 1 for ribociclib to be used as adjuvant treatment in combination with an ...

Image credit: Shutterstock / LCV Sanofi will halt the development of its oral tumour necrosis factor (TNF) inhibitor balinatunfib as a monotherapy after it failed to reach the primary endpoint in a ...

A Comprehensive Guide to Aromatase Inhibitors: Essential Tools for Managing Hormone Receptor-Positive Breast Cancer Presented by Learn Look Locate and Walgreens “We know that understanding your ...

In recent years, structure-based drug design has facilitated the development of lysine-targeting covalent inhibitors. The CoDEL technology is rapidly emerging as a key platform for covalent drug ...

Brensocatib, an oral, reversible inhibitor of dipeptidyl peptidase 1 (DPP-1), targets neutrophil serine proteases, key mediators of neutrophilic inflammation. In a phase 3, double-blind trial ...