1-9 These therapies incorporate either a 4-1BB (CD137) or a CD28 intracellular costimulatory domain to enhance T-cell activation and persistence. Despite these advancements, more than 50% of ...

where they undergo positive and negative selection to produce a nonself-binding T-cell antigen receptor, and emerge as naive, single, positive T cells. After encountering antigen in the periphery ...

T cells were stimulated with 5 μg/ml AH1-peptide (SPSYVYHQF) or plate-bound monoclonal antibody (mouse: anti-α/β TCR (H57-597) anti-CD28 (37.51, both Pharmingen, San Diego, California); TIL-26 ...

[7] Increased autoimmunity appears to be primarily the result of the combined effects of the reduction in naive T cells (produced by thymus involution) in concert with an activation of self ...

Tregs, or T-regulatory cells, have shown promise in fighting autoimmune ... Ferreira noted that the team also made sure to run tests on both naive Tregs and memory Tregs to be sure that their ...