CDK12 is known to play a role in about 7% of metastatic prostate cancers and about 3% of tubo-ovarian high-grade serous cancers. It has not been shown to be inactivated in other cancer types.

A promising degrader targeting CDK12 and a related gene, CDK13, can destroy these tumors. This is the first demonstration of in a mouse model that CDK12 plays a tumor suppressor role in this type ...

A new study explains the genetic underpinnings of a rare and aggressive form of ovarian cancer – and offers a potential pathway ...

HRR gene alterations: changes in genes like BRCA1 or BRCA2 that affect the cell’s ability to repair DNA damage. Radiographic progression-free survival ... CDK12, CHEK2, FANCA, PALB2, RAD51B or RAD54L.

Climate Solutions A gene could be key to growing rice, and feeding billions, in a hotter world. Researchers say they can improve rice harvests and grain quality by essentially turning off a ...

It's official: Gene Wojciechowski is no longer an official part of ESPN. Wojciechowski made the announcement this weekend on X (formerly Twitter): "After 27 1/2 yrs, my official last day on the ...

Personalized gene editing saved a baby, but the tech’s future is uncertain. Costs, government regulation and lack of know-how could hinder wider use of the CRISPR tech ...

Gene editing holds the potential of suppressing mosquito species that carry deadly diseases — and raises ethical questions.

Gene Wojciechowski was let go during ESPN's layoffs in 2023, but that didn't stop an array of tributes to his career over the weekend. Sports newsletter 🏈's best, via 📧 Studio IX 🏀⚽️ ...

The well-studied NF-κB signaling system is a key mediator of the inflammatory response. Large-scale sequencing studies in ...