Traumatic brain injury (TBI) induces profound functional heterogeneity in astrocytes, yet the regulatory mechanisms underlying this diversity remain poorly understood. In this study, we analyzed ...

Cartoon summarizing the principal metabolic pathways deregulated in Autosomal Dominant Polycystic ... including mitochondria fragmentation and reduced calcium uptake. Left: Primary cilia play a ...

Calcium homeostasis is an important aspect of maternal and fetal physiology during gestation, since fetal bone mineralization requires adaptive adjustments in maternal calcium regulation.

Diabetes mellitus (DM) is a chronic metabolic disorder marked by sustained hyperglycemia ... and restoring mitochondrial homeostasis via activation of core signaling pathways (e.g., PINK1/Parkin, ...

Notably, therapies targeting metabolic pathways, particularly those involving mitochondrial metabolism, such as the peroxisome proliferator-activated nuclear receptor γ (PPARγ) agonists, are currently ...

School of Civil and Environmental Engineering, Nanyang Technological University, Singapore 639798, Singapore College of Environmental Science and Engineering, State Environmental Protection ...