Disrupting the G-loop cycle causes transcriptome dysregulation and genome instability, revealing key role in cell survival ...

Researchers have identified a form of molecular motion that has not previously been observed. When what are known as "guest molecules"—molecules that are accommodated within a host molecule—penetrate ...

Not all DNA looks like the familiar twisted ladder. Sometimes, parts of our genetic code fold into unusual shapes. One such structure, the G-quadruplex (G4), looks like a knot. These knots can play ...

CHAF1B, a histone chaperone component of the chromatin assembly factor-1 complex, is overexpressed in multiple cancers and ...

Researchers are beginning to unpick the intricate molecular choreography that ensures faithful transmission of genetic and ...

The small study in patients with a rare disorder that causes liver and lung damage showed the potential for precisely targeted infusions. By Gina Kolata Researchers have corrected a disease ...

as a chromatin-associated protein required to promote ongoing replication, fork restart, telomere maintenance, cellular survival following hydroxyurea or pyridostatin treatment, and suppression of DNA ...

2024.07.017]. The scientists determined that Mrc1 and Mcm2 form a co-chaperone complex, ensuring distribution of histones to the lagging strand during DNA replication. In mutants of Mrc1 ...

This type of DNA damage can occur through endogenous metabolic ... FLIP(C1orf112)-FIGNL1 complex regulates RAD51 chromatin association to promote viability after replication stress. Nature ...

However, whether transcription plays a greater role in the organization of chromatin following DNA replication remains unclear. Here we analysed protein re-association with newly replicated DNA upon ...

Specifically, during DNA replication, replication forks stall at DPCs and are ... In cells, the mutants also displayed reduced auto-cleavage, but their accumulation at the chromatin upon formaldehyde ...