The map uncovered insights into the mechanisms of drug resistance, highlighting DNA changes that may be potential treatment biomarkers, and identifying promising combination or second-line therapies.

The discovery in the 1990s that a mutation in a single gene of an experimental worm could double its lifespan set off a stampede of research on the molecular biology of aging and triggered hopes ...

An artistic rendering of the concept of DNA ... A process called DNA damage response has evolved to repair errors and mutations. Researchers have produced a new map that more fully captures ...

Scientists are decoding the genetic mechanisms of aging. ScienceDaily . Retrieved June 2, 2025 from www.sciencedaily.com / releases / 2019 / 10 / 191010142059.htm ...

Genome encyclopedia A massive DNA database has generated a map of the genetic switches that ... very valuable leads to follow to discover key mechanisms at play in health and disease," says ...

Producing the first detailed map ... the mechanisms contributing to cancer development. A range of exogenous factors, including tobacco smoke and radiation can cause damage to cellular DNA.

CRISPR and similar gene editing tools rely on interactions with endogenous DNA repair mechanisms, like DNA double-strand breaks ... "Repair-seq is an experimental approach for systematically mapping ...

How do DNA repair mechanisms detect and repair damaged DNA, and what happens when they fail? Defects in DNA repair underlie a number of human genetic diseases that affect a wide variety of body ...

Standard genetic ... to map out the tumor microenvironment and where it interacts with the immune system. Immune cells interact with each other and respond to pathogens in context-specific ways, so ...

Northwestern Medicine investigators have discovered new molecular mechanisms underlying DNA repair dysregulation in prostate cancer cells, findings that may inform the development of new targeted ...