DNA replication is the biological ... Each of the two strands of the DNA molecule acts as a template for the synthesis of a complementary strand. The replicative helicase CMG is targeted for ...

In the cell, each of the two strands of the DNA molecule acts as a template for the synthesis ... use different mechanisms for strand separation during replication. Here, the authors reveal ...

Replicative DNA polymerases (Pol) function with a sliding clamp and ... The primer is unwound by six nucleotides that scrunches to form out-of-register base pairs with the template. These findings ...

Researchers discovered a previously unknown function of RNA, potentially opening the door to new ways to treat cancer and ...

Disrupting the G-loop cycle causes transcriptome dysregulation and genome instability, revealing key role in cell survival and homeostasis.

“PDI is like a double agent,” Dr Shadfar explains. “In healthy cells, it repairs DNA and helps prevent disease. But in cancer ...

Experiments with tools designed to detect DNA damage reveal unique and conserved features of telomeres in cancer cells.

A new study in Nature Plants reveals that DNA double-strand break repair (DSBR) pathways help prevent gene transfer from organelles to the nucleus in plants. Disruption of DSBR increases the risk of ...

Viruses are entirely dependent on their hosts to reproduce. They ransack living cells for parts and energy and hijack the ...

Not all DNA looks like the familiar twisted ladder. Sometimes, parts of our genetic code fold into unusual shapes. One such structure, the G-quadruplex (G4), looks like a knot. These knots can ...

Find more information on the Altmetric Attention Score and how the score is calculated. Parallel-stranded (ps) DNA characterized by its sugar–phosphate backbones pointing in the same direction ...

The RNA Institute, University at Albany, State University of New York, Albany, New York 12222, United States Department of Biological Sciences, University at Albany, State University of New York, ...