Tuberculosis is the world's leading infectious cause of death, killing more than one million people each year. When the ...

Efflux pump proteins are present in many human cells and often share structural similarities, so further research will need to investigate how specific this novel inhibitor is in targeting cancer ...

Chemists have synthesized a new compound that makes drug-resistant bacteria susceptible again to antibiotics. The compound -- BU-005 -- blocks pumps that a bacterium employs to expel an ...

Get Instant Summarized Text (Gist) A novel inhibitor capable of disabling a key Mycobacterium tuberculosis efflux pump has been identified, and the complete structure of this pump has been mapped.

Many bacteria are able to survive in the presence of antibiotics in part because they possess pumps that can remove a broad range of small molecules; here, the structure of one such pump, AcrAB ...

The efflux pumps had, in effect, given the microbes the exact loophole they needed to resolve the protein synthesis paradox. The pumps weren’t enough to confer drug resistance on their own ...

Finding a way to disable the efflux transporters of M. tuberculosis with an inhibitor would strike a double blow — restore microbial sensitivity to antibiotic bedaquiline and break the cycle that ...

Crestone Inc. and the University of Colorado have reported efflux pump (bacterial) inhibitors potentially useful for the treatment of Gram-negative bacterial infections. BioWorld Science Infection ...

The classic multidrug-resistance (MDR) phenotype, as mediated by the drug efflux pump, P-glycoprotein, is one of the most extensively studied mechanisms of drug resistance. Additional drug ...

How Bacteria Can Escape Destruction: Scientists Discover Mechanism Used To Pump Out Drugs. ScienceDaily . Retrieved March 7, 2025 from www.sciencedaily.com / releases / 2006 / 12 / 061226095406.htm ...

Crestone Inc. and the University of Colorado have reported efflux pump (bacterial) inhibitors potentially useful for the treatment of Gram-negative bacterial infections. BioWorld Science Infection ...