Finding a way to disable the efflux transporters of M. tuberculosis with an inhibitor would strike a double blow — restore microbial sensitivity to antibiotic bedaquiline and break the cycle that ...

The protein MmpL5 is an efflux transporter, a critical pump that helps the pathogen M. tuberculosis grow by scavenging essential iron. Unfortunately, overexpressed MmpL5 can also pump out ...

Get Instant Summarized Text (Gist) A novel inhibitor capable of disabling a key Mycobacterium tuberculosis efflux pump has been identified, and the complete structure of this pump has been mapped.

Tuberculosis is the world's leading infectious cause of death, killing more than one million people each year. When the ...

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An efflux pump is a mechanism used by bacteria to actively transport antibiotics out of the cell, reducing the drugs’ effectiveness. The role of the MAB_2302-MAB_2303 gene pair as a direct efflux pump ...

Efflux as a mechanism of tachyplesin resistance has been shown at the population level in tachyplesin-resistant P. aeruginosa via transcriptome analysis 60,66, whereas phenotypic resistance to ...