Finding a way to disable the efflux transporters of M. tuberculosis with an inhibitor would strike a double blow — restore microbial sensitivity to antibiotic bedaquiline and break the cycle that ...

Tuberculosis is the world's leading infectious cause of death, killing more than one million people each year. When the ...

The protein MmpL5 is an efflux transporter, a critical pump that helps the pathogen M. tuberculosis grow by scavenging essential iron. Unfortunately, overexpressed MmpL5 can also pump out ...

Discover how antibiotic resistance is transforming routine infections into deadly threats. Learn the shocking truth about 10 ...

Researchers from King's College London have called for urgent changes to the way new antibiotics are developed to address the ...

Reviewer #3 (Public review): Summary: This important study shows that stationary phase bacteria survive antimicrobial peptide treatment by switching on efflux pumps, generating low accumulating ...

Considering that the AcrAB-TolC tripartite RND efflux system is known to confer genetic resistance against AMPs like protamine and polymyxin-B 29,30 and that the quorum sensing regulators qseBC might ...

Universal embezzlers naturally emerge in critical fermion systems, study finds. Jun 21, 2025. ... A novel inhibitor capable of disabling a key Mycobacterium tuberculosis efflux pump has been ...