Tuberculosis is the world's leading infectious cause of death, killing more than one million people each year. When the ...

The protein MmpL5 is an efflux transporter, a critical pump that helps the pathogen M. tuberculosis grow by scavenging essential iron. Unfortunately, overexpressed MmpL5 can also pump out ...

Finding a way to disable the efflux transporters of M. tuberculosis with an inhibitor would strike a double blow — restore microbial sensitivity to antibiotic bedaquiline and break the cycle that ...

Efflux Pump’s Shape Shifting Sheds Light on Antibiotic Resistance February 18, 2022 MIT chemists have discovered how the structure of the EmrE transporter changes as a compound moves through it.

A multidrug efflux pump in motion Date: March 13, 2017 ... ' for pumping chemotherapeutic drugs out of cancer cells and blocking medications from reaching the central nervous system.

Structural basis for inhibition of the drug efflux pump NorA from Staphylococcus aureus. Nature Chemical Biology , 2022; DOI: 10.1038/s41589-022-00994-9 Cite This Page : ...

SURFSIDE, FL--(Marketwired - Mar 27, 2014) - NanoAntibiotics (OTCBB: NNAB) (the "Company"), a development stage nano-biotechnology company focused on the discovery, development, and commercialization ...

Universal embezzlers naturally emerge in critical fermion systems, study finds. Jun 21, 2025. ... A novel inhibitor capable of disabling a key Mycobacterium tuberculosis efflux pump has been ...

P-glycoprotein is an ABC transporter of the efflux class that functions to remove molecules from inside the cell, including cytotoxic drugs. In this way it controls the body's pharmacokinetic profile.