Therefore, a complex mesenchymal–epithelial signaling network has been implicated to play a pivotal role in organogenesis through its interactions with other germ layers ... During mouse embryonic ...

As well as being essential in the precise packaging of DNA into the space of the nucleus, histone proteins are also the site ...

New research has investigated the mechanism by which bivalency functions to poise genes for expression during cell differentiation, providing insight into a long-standing paradigm in the regulation of ...

This valuable study presents a mouse gastruloid model that can be used to generate hematopoietic progenitors as well as leukemic cells. However, in its current form, the manuscript is inadequate ...

First Mouse With Two Male Parents to Reach Adulthood Jan. 28, 2025 — A team of stem cell scientists have successfully used embryonic stem cell engineering to create a bi-paternal mouse -- a ...

The authors describe a method for gastruloid formation using mouse embryonic stem cells (mESCs) to study YS and AGM-like hematopoietic differentiation. They characterise the gastruloids during nine ...

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Embryonic stem cells (ESCs), which are characterized by the capacity for self-renewal and pluripotency, hold great promise for regenerative medicine. Increasing evidence points to the essential role ...