Chemoattractants direct the extravasation of leukocytes to the site of immune response. New data highlight the role of synaptotagmins and Rab proteins in leukocyte chemotaxis. You have full access ...

Interactions of neutrophils (red) and iMOs (green) with endothelial cells (blue) were analyzed in the microvasculature of the cremaster muscle of CX3CR1GFP/+ mice by multichannel in vivo microscopy (A ...

At sites of infection or inflammation, these leukocyte integrins become activated and mediate adhesion and extravasation of the leukocyte into the infected tissue.

We examined the behavior of polymorphonuclear leukocytes (PMNs) and monocytes during subcutaneous plasma extravasation in guinea-pigs. Plasma extravasation was induced by intradermal injection of ...

Regulation of vascular permeability and leukocyte extravasation in inflammation: mechanisms and heterogeneity in different organs. Principal investigator: Dietmar Vestweber Project number: ... In a ...

Most leukocytes express L-selectin, but E-selectin and P-selectin are only secreted by inflamed endothelial cells. ... Extravasation of Neutrophils Play. The activation and arrest of leukocytes.

The β2 common integrin subunit CD18 is essential for leukocyte–endothelial adhesion and extravasation to inflamed or infected tissue. Damaging variants in ITGB2, which encodes CD18, cause ...

White blood cells attack infected cells. ... Extravasation is a process wherein leukocytes migrate from the tissues to the blood and from the lymphatic vessels back into the tissues.

Prof. Dr. Lydia Sorokin NO positions via CiM-IMPRS in 2025 Mechanisms of Leukocyte Transmigration Across Basement Membranes. Immunofluorescence staining for the basement membrane component, laminin ...

Extravasation, the leakage of infusion fluids into surrounding tissues, is a significant concern that can lead to severe ...

A previously unrecognised role of platelets as the pathfinders for leukocyte extravasation during inflammation has been reported in PLOS Biology 1.. Using a combination of in vivo video imaging, ...