The newly rearranged T cell receptor on the surface of immature thymocytes must interact with not too much and not too little affinity for self-peptide–MHC ligands to allow the cell to mature ...

Lrrk2 promotes the accumulation of a-synuclein deposits by an unknown mechanism, and evidence shows that autophagy slows in cells expressing pathogenic LRRK2 variants. Exactly how mutations predispose ...

Liu will examine whether the LRRK2 inhibitor is also effective in killing AML cells with high levels of LRRK2. She will test her theories in both cell culture studies and mouse models. Liu hopes to ...

Pivotal Phase 3 VERITAC-2 clinical trial results presented at ASCO demonstrate 2.9-month improvement in median progression-free survival when compared to fulvestrant in second line-plus patients ...

Arvinas is currently progressing multiple investigational drugs through clinical development programs, including vepdegestrant, targeting the estrogen receptor for patients with locally advanced ...

This week's round-up of new financings in the biotech world is headed by a big round for Third Arc, a specialist in T-cell engager antibodies, with Autobahn, Brenig, Confo, and GRO Bio also in on ...

Parkinson’s disease is a neurodegenerative disorder that affects the nervous system. Studies show that some cases are caused by genetic mutations, but hereditary causes are rare. Hereditary ...

Tyrosine phosphorylation of membrane receptors and scaffold proteins followed by recruitment of SH2 domain-containing adaptor proteins constitutes a central mechanism of intracellular signal ...

Phosphorylation of the human p52Shc adaptor protein is a key determinant in modulating signaling complex assembly in response to tyrosine kinase signaling cascade activation. The underlying mechanisms ...

The importance of endolysosomal trafficking for neuronal health is indicated by the number and diversity of genes in the pathway that are risk variants across neurodegenerative diseases, ranging from ...