The insulin and the IGF-1 pathway are closely intertwined. Both can bind the insulin receptor or the IGF receptor 1 (IGFR-1). IGF-2, on the other hand, can bind either IGFR-1 or the high-affinity IGFR ...
Rather than representing a distinct gene product, this peptide arises from alternative splicing events within the IGF-1 gene locus, leading to a unique E-domain sequence with properties that diverge f ...
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