The RAS–mitogen activated protein kinase (MAPK) signalling pathway has long been viewed as an attractive pathway for anticancer therapies, based on its central role in regulating the growth and ...

Researchers at the Francis Crick Institute have shown that the 'pacemaker' controlling yeast cell division lies inside the ...

Epithelial cell transcytosis of polymeric IgA by its receptor requires polarized membrane trafficking. A signalling cascade involving the tyrosine kinase YES, EGFR, ERK and the Rab11 effector FIP5 ...

The three-kinase cascade, a module conserved from yeast to humans and which comprises a MAPK, MAP2K, and MAP3K, is the most easily recognizable property of MAPK signaling.

Scientists have achieved a quantitative in vivo measurement of the dynamic protein-protein interactions in the mitogen-activated protein kinase cascade signaling pathway, which is critical to ...

Phosphatidylinositol 3-kinase (PI3K) is involved in multiple ... a bona fide tumor-suppressor gene. 36 Together with the frequent alterations in other components of the PI3K signaling cascade, ...

In a canonical MAPK cascade, a MAPK kinase kinase (MAP3K) activates a MAPK kinase (MAP2K) by phosphorylating two conserved Ser/Thr residues in the activation loop.

You’ve got to love a signaling cascade that includes the enzyme MAP kinase, which is phosphorylated by MAP kinase kinase, which is in turn phosphorylated by MAP kinase kinase kinase. The MAP ...

Normally, the protein inhibits an important signal pathway of the cell, the so-called Ras/ERK-MAP kinase cascade. When it is missing, this signal pathway is more active than usual.

Upon aversive stimulus (electric foot shock), acetylcholine activates PAK kinase through the M1R-PKC cascade to facilitate synaptic plasticity.