A new once-day pill made by AstraZeneca has the ability to delay breast cancer progression in those in the advanced stages ...

Targeted Oncology connects oncology professionals with updates on immunotherapy, biomarkers, cancer pathways, and targeted ...

Genetic mechanisms of drug resistance. Target Drug(s) Indication(s) Resistance mechanisms Ref. EGFR: Erlotinib: NSCLC: MET amplification, T790M gatekeeper mutation, PTEN loss, HER2 kinase domain ...

Researchers have unveiled a novel immune mechanism by which tandem kinases combat pathogen invasion: an atypical NLR protein, WTN1 (Wheat Tandem NBD 1), partners with the tandem kinase WTK3 to ...

If you inhibit this kinase, the forks cannot slow down anymore,” Smolka said. The researchers applied these findings in a model of BRCA2 deficient breast cancer to better understand the ...

“The tyrosine kinase inhibitors represent a new mechanism of action where these TKIs — vorolanib, sunitinib and axitinib — actually act intracellularly to act as pan-VEGF, FGF and PDGF ...

It is known that the molecular mechanism underlying this reward behavior involves a signaling cascade that increases the "phosphorylation" (the attachment of a phosphate group) of protein kinase A ...

Scientists uncover novel immune mechanism in wheat tandem kinase. Chinese Academy of Sciences Headquarters. Journal Science DOI 10.1126/science.adp5469. Keywords ...