If mesna is used, it can be dosed IV at approximately 20% of the CYC dose. For example, if 1000 mg of CYC is given, then a total dose of 200 mg of mesna is given, divided into 3 doses (usually ...

Mesna generic Mesna is prescribed as a preventive medicine to reduce the risk of hemorrhagic cystitis caused by the chemotherapy drugs ifosfamide and cyclophosphamide. Hemorrhagic cystitis is a ...

There is a dose-response relationship between cumulative cyclophosphamide dose and risk of bladder cancer in Wegener's granulomatosis. (Knight A et al, 2004; 63:1307-1311.) ...

The experimental-prophylaxis regimen consisted of the following: cyclophosphamide (50 mg per kilogram per day on days 3 and 4 after HSCT) with mesna and hydration (details are provided in the ...

All patients receiving cyclophosphamide also received mesna (Mesnex, Bristol-Myers Squibb) to prevent hemorrhagic cystitis and granisetron hydrochloride (Kytril, GlaxoSmithKline) ...

followed by 1,500 mg/m 2 cyclophosphamide, and mesna once every 3 weeks. Dose escalation of tirapazamine began at 250 mg/m 2 and was increased by 30% in subsequent cohorts. If DLT was hematologic, ...

Cyclophosphamide is one of the most widely utilized chemotherapeutic and immunosuppressive agents in many combination chemotherapy regimens and autoimmune conditions. This Review highlights the ...

Review the side-effects of Mesna as documented in medical literature. The term "side effects" refers to unintended effects that can occur as a result of taking the medication. In majority of the ...

Dose-limiting toxicity of grade 4 neutropenia for longer than 5 days and grade 4 thrombocytopenia occurred in three of five patients treated with paclitaxel 160 mg/m2 CIVI and cyclophosphamide 3,300 ...