Similarly, the phosphorylation of enzymes such as glycogen phosphorylase and certain protein kinases induces conformational changes in their catalytic domains, which allows substrates to access ...

the authors show that phosphorylation of Cdk1 substrates is influenced by a phosphate-binding pocket on the surface of the cyclin regulatory subunit. Filamin C is a key actin-binding protein ...

CARDIFF, UNITED KINGDOM / ACCESS Newswire / June 18, 2025 / When it comes to type 1 diabetes, treating this chronic condition ...

[26–28] Such approaches also led to the identification of 65 candidate substrates ... these phosphorylation studies by using this same approach to analyze nearly every yeast protein kinase ...

CARDIFF, UNITED KINGDOM / ACCESS Newswire / June 18, 2025 / When it comes to type 1 diabetes, treating this chronic condition ...

The phosphorylation of cognate substrates by protein kinases is regulated in a variety of ways (Cullati et al., 2022; Sang et al., 2022). IKK2, a kinase central to inflammation, phosphorylates serine ...

Strengths: The authors provide an extensive biochemical characterization of the processes with recombinant protein, western blot ... near the activate site facilitates phosphorylation of the serine on ...

A study in Oncogene shows that PPP2R1A mutations increase sensitivity to ATR inhibitors in ARID1A-mutant ovarian clear cell ...

CDK-1 mediated phosphorylation of the centriolar cartwheel protein SAS-6 regulates its phase separation ... cyclin-dependent kinase 1 (CDK-1), suggesting that SAS-6 is a potential substrate of CDK-1.

A University of Alberta research team has identified a key protein involved in the normal growth of mammary glands during ...

Amplifye, a startup led by former Amyris CEO John Melo, has launched its first product: an enzyme claimed to optimize protein ...

Two key protein structures in the body are being visualized for the first time, thanks in part to the latest technology in ...