From the time we are conceived and through old age, genetic mutations accumulate in all our tissues, eluding the body's ...

Dr. Evan Yu presents the new evidence-based guideline on genetic testing for metastatic prostate cancer. He discusses who should receive germline and somatic testing with next-generation sequencing ...

Institutions worldwide can enhance their research with an easy-to-adopt matched tumor-normal workflow, improving somatic detection rate for robust precision oncology insights. References Jones, S ...

This study compared somatic and germline classifications of small nucleotide variants in the following genes: BRCA1, BRCA2, CHEK2, PALB2, ATM, MLH1, MSH2, MSH6, and PMS2.Somatic classifications were ...

Drs Sandhya Srinivas and Heather Cheng discuss PARP inhibitors, clinical trials, and germline vs somatic testing for patients with prostate cancer, as well as the optimal time for this testing.

A somatic cell is generally taken to mean any cell forming the body of an organism. Somatic cells, by definition, are not germline cells. In mammals, germline cells are the sperm and ova (also ...

A new multicenter study by researchers at the Icahn School of Medicine at Mount Sinai, in collaboration with the Clinical ...

Somatic human genome editing has made huge strides in the past five years, but the likely extremely high prices will be unsustainable. A global commitment to affordable, ... Somatic genome editing ...

The group analyzed 43,693 blood sample whole genomes from 37 cohorts and identified 7,131 non-missense somatic mutations that are recurrently mutated in at least 50 individuals. According to the ...