From the time we are conceived and through old age, genetic mutations accumulate in all our tissues, eluding the body's ...

Mismatch repair (MMR) germline alterations are enriched among patients with uveal melanoma (UM), according to a study ...

Animals, from worms and sponges to jellyfish and whales, contain anywhere from a few thousand to tens of trillions of nearly genetically identical cells. Depending on the organism, these cells arrange ...

HRD tumors because of BRCA loss are uniquely sensitized to PARP inhibition because of a synthetic lethal interaction between BRCA and PARP. 56, 57 HRD tumors manifest a characteristic and identifiable ...

The steady march toward realizing genetic medicine's potential has continued, particularly in oncology. Based on high germline diagnostic yields of over 10%, clinical cancer guidelines now recommend ...