The interactions between transcription factors guided by DNA are poorly understood. In a new study, researchers from the Sanger Institute and the University of Cambridge used two novel algorithms ...

Investigating how mutations in tumors alter DNA’s 3D structure—and subsequently, regulatory sequences called enhancers—can ...

Transcription factors are proteins that bind to specific DNA sequences to control gene expression, guiding cells to become ...

A new study from the University of Michigan Rogel Health Cancer Center, published in Science, sheds light on how two distinct ...

Zhiyuan Xie et al. (2025) ‘DNA-guided transcription factor interactions extend human gene regulatory code.’ Nature. DOI: 10.1038/s41586-025-08844-z . Funding: ...

In the field of molecular biology, a transcription factor (sometimes called a sequence-specific DNA binding factor) is a protein that binds to specific DNA sequences and thereby controls the ...

A new study from the University of Michigan Rogel Health Cancer Center, published in Science , sheds light on how two ...

The team applied this tool to immature blood cells to identify the important transcription factors – and DNA regions that code for them – that strongly affect how blood cells develop. They discovered ...

In diseases due to exposure to toxic particles like gout, macrophages elicit separate pathways for inflammation and lysosomal ...

Then they analyzed the DNA sequences of those bits to map where all the transcription factors attach. They found instances where a transcription factor binds to DNA and regulates the nearby gene, just ...

Our laboratory investigates how transcription factors, DNA damage response proteins, and epigenetic modifications induce changes in the structure, dynamics, and interactions of chromatin. We are also ...