The ERBB receptors are a group of receptor tyrosine kinases (RTKs ... Eigenbrot, C. Structure of the epidermal growth factor receptor kinase domain alone and in complex with a 4-anilinoquinazoline ...

Recent research sheds light on how changes in the chemical structure of a protein ... that usually block cancer growth, such as tyrosine kinase inhibitors, which are drugs designed to interrupt ...

Currently, five tyrosine kinase inhibitors (TKIs—imatinib ... The ASC4FIRST trial has confirmed that tolerability and molecular response with asciminib are superior to those with both imatinib and the ...