SANTA CLARA, Calif. — The San Francisco 49ers have played games without Deebo Samuel Sr. in the last year and a half. And ...

The 49ers are partly to blame for why Christian McCaffrey will be out at least four games and possibly more as he nurses ...

McCaffrey won NFL Offensive Player of the Year in 2023 and helped the 49ers reach Super Bowl 58. He’s produced 2,205 rushing ...

San Francisco 49ers star Christian McCaffrey could miss more than the minimum of four games required on injured reserve, ...

ESPN sources: 49ers officially are placing All-Pro RB Christian McCaffrey on injured reserve due to his calf tightness and ...

San Francisco 49ers running back Christian McCaffrey is going to be out for at least the next four games. Per ESPN's Adam ...

The San Francisco 49ers are without running back Christian McCaffrey for at least four weeks. A report from NFL Media’s Ian ...

The San Francisco 49ers have placed All-Pro running back Christian McCaffrey on injured reserve because of his lingering calf ...

Christian McCaffrey will miss at least the 49ers’ first five games this season as they put him on the injured reserve list ...

The San Francisco 49ers have ruled out Christian McCaffrey for Week 2 vs. the Minnesota Vikings — and potentially longer.

The reigning NFC champions faced a puzzling loss on Sunday. The San Francisco 49ers lost to the Minnesota Vikings 23-17 as ...

The 49ers revealed their status reports Friday for their injured players ahead of Sunday’s visit to the Los Angeles Rams.