A Scripps team has adapted advanced imaging and computation to measure cell membrane thickness inside intact animal and yeast ...

GROUNDBREAKING Phase 2 clinical trial data show that sorfequiline, combined with pretomanid and linezolid (SPaL), may enhance efficacy and safety in drug-sensitive tuberculosis (TB). The NC-009 trial, ...

TMC207 is a first-in-class anti-TB diarylquinoline (also named R207910 or the 'J' compound) with activity against drug-sensitive and drug-resistant TB. TMC207 inhibits the proton pump of mycobacterial ...

Mineralys Therapeutics’ aldosterone synthase inhibitor has chalked up a third clinical win in recent months, demonstrating once again its potential to reduce blood pressure in patients with ...

In aerobic organisms, the electron transport chain (ETC) and ATP synthase are central to the conversion of nutrients into the universal cellular energy currency, adenosine triphosphate (ATP). Due to ...

In a recent study published in Nature, researchers from the United States of America investigated how cells separate competing metabolic pathways within mitochondria, namely oxidative phosphorylation ...

Lena Pernas is in the Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, California 90095, USA, and the Howard Hughes Medical Institute, ...

A team has made a groundbreaking discovery in the field of aging and inflammation. Japan's aging population is growing at an unprecedented rate, making it crucial to extend healthy lifespans rather ...

Cyclic GMP-AMP synthase (cGAS) functions as a foreign DNA sensor, triggering an immune response to pathogens by activating the STING (stimulator of interferon genes) receptor. Shortly after its ...

The cells of all living organisms are powered by the same chemical fuel: adenosine triphosphate (ATP). Now, researchers have found a way to generate ATP directly from electricity, which could ...